Composition:
Tizanidine hydrochloride 4mg (scored tablet).
Properties:
Tizyl is a centrally acting skeletal muscle relaxant; its major site of action is in the spinal cord. It preferentially inhibits polysynaptic mechanisms responsible for excessive muscle tone, mainly by reducing the release of excitatory amino acids from interneurons. The drug does not affect neuromuscular transmission. It is well tolerated and effective against both acute painful muscle spasms and chronic spasticity of spinal and cerebral origin. It reduces resistance to passive movements, alleviates spasms and clonus, and improves voluntary strength.
Indications:
Painful muscle spasms
- Associated with static and functional disorders of the spine (cervical and lumbar syndromes).
- Following surgery, e.g. for herniated intervertebral disc or for osteoarthritis of the hip.
Spasticity due to neurological disorders e.g. multiple sclerosis (M.S), chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents and cerebral palsy.
Dosage:
2 to 4 mg three times daily.
The dosage should be adjusted to the needs of the individual patient.
The daily dose may be increased stepwise at half – weekly intervals by 2 to 4 mg. The daily dose of 36 mg should not be exceeded.
Precautions:
In patients with renal insufficiency (creatinine clearance less than 25 ml / min) or with severly impaired liver function, it is recommended to start treatment at 2 mg once daily. Dosage increases should be done in small steps according to tolerability and efficacy.
Interactions:
Concomitant use of Tizyl with antihypertensive, including diuretics, may occasionally cause hypotension and bradycardia. Alcohol or sedatives may enhance the sedative action of Tizyl.
Package:
10 scored tablets/strip.